Rp-8-pCPT-cGMPS (sodium)
CAS No. : 208445-07-2
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| Cat. No. : | HY-110221 |
| M.Wt: | 525.86 |
| Formula: | C16H14ClN5NaO6PS2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Rp-8-pCPT-cGMPS sodium is the sodium salt form of Rp-8-pCPT-cGMPS. Rp-8-pCPT-cGMPS is an inhibitor for cGMP-dependent protein kinase (cGK). Rp-8-pCPT-cGMPS sodium is an agonist for cyclic nucleotide-gated (CNG) channels in a voltage-dependent manner[1][2]. In Vivo:Rp-8-pCPT-cGMPS sodium (5 nM, intrathecally, once a day for 3 days) inhibits the cGMP-cGKI pathway, suppresses tumor cell implantation (TCI)-induced thermal hyperalgesia and mechanical allodynia in Sprague-Dawley rats model[1].
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