MRT68921 (dihydrochloride)
CAS No. : 2080306-21-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $34 | In-stock |
| 5mg | $72 | In-stock |
| 10mg | $120 | In-stock |
| 25mg | $240 | In-stock |
| 50mg | $432 | In-stock |
| 100mg | $564 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100006A |
| M.Wt: | 507.50 |
| Formula: | C25H36Cl2N6O |
| Purity: | >98 % |
| Solubility: | H2O : 20.83 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : 8.33 mg/mL (ultrasonic;warming;heat to 60°C) |
MRT68921 dihydrochloride is a potent NUAK1/ULK1 dual inhibitor. MRT68921 dihydrochloride inhibits ULK1 and ULK2 with IC50 values of 2.9 nM and 1.1 nM, respectively. MRT68921 dihydrochloride can block cells autophagy and kill tumor cells by breaking the balance of oxidative stress signals. MRT68921 dihydrochloride can inhibit cell proliferation and induce ROS production and apoptosis. MRT68921 dihydrochloride can be used for the research of cancer, such as breast cancer[1][2].
In Vitro:MRT68921 dihydrochloride (1 μM, 1 h) reduces basal LC3 puncta and blocks basal autophagy in mouse embryonic fibroblasts (MEFs)[1].
MRT68921 dihydrochloride (1 μM) reduces LC3-II levels in TBK1 knock-out and matched wild-type MEFs[1].
MRT68921 dihydrochloride (24 h) exhibits cytotoxic activity in cancer cells with IC50 values ranging from 1.76-8.91 μM[2].
MRT68921 dihydrochloride (0-10 μM, 8-24 h) induces ROS production and apoptosis in NCI-H460 and MNK45 cells[2].
MRT68921 dihydrochloride (0-5 μM, 8h) suppresses the NUAK1/MYPT1/Gsk3β andautophagy associated signaling pathway in U251 and MNK45 cells[2].
In Vivo:MRT68921 dihydrochloride (10-40 mg/kg, s.c., daily for 7 times) inhibits tumor growth in NCI-H460 tumor mice models[2].
MRT68921 dihydrochloride (20 mg/kg, s.c., every 2 days for 7 times) inhibits tumor growth in MNK45 tumor mice models[2].
MRT68921 dihydrochloride (20 mg/kg, i.p., daily for 7 times) reduces the number of lung metastatic nodules in 4T1 tumor mice models[2].
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