SB-203186 (hydrochloride)
CAS No. : 207572-69-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $70 | In-stock |
| 10mg | $120 | In-stock |
| 25mg | $250 | In-stock |
| 50mg | $400 | In-stock |
| 100mg | $600 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-101222 |
| M.Wt: | 308.80 |
| Formula: | C16H21ClN2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
SB-203186 hydrochloride is a potent, selective and competitive 5-HT4 antagonist. SB-203186 hydrochloride antagonizes the 5-HT4 receptor-mediated relaxations of the carbachol-contracted rat isolated oesophagus against 5-HT with pKB values of 10.9 (rat oesophagus), 9.5 (guinea-pig ileum), and 9.0 (human colon) respectively[1][2][3].
IC50 & Target: pKB: 10.9 (5-HT4 in rat oesophagus), 9.5 (5-HT4 in guinea-pig ileum), and 9.0 (5-HT4 in human colon)[3].
In Vitro: Pretreatment with SB-203186 (10 μM) enhances the 5-HT-induced contractions of the antral strips[2].
In Vivo: Intraduodenally administered SB-203186 (0.3-3 mg/kg) to new-born Camborough piglets produced blockade of 5-HT-evoked tachycardia which was maximal after 20 min and lasted for more than 3 h with 0.3 mg/kg[1].
SB-203186 (0.1-3mg/kg, i.v.) surmountably antagonised 5-HT-evoked tachycardia in anaesthetized Yucatan minipigs or new-born Camborough piglets with similar potency[1].
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