NVP-DPP728 (dihydrochloride)
CAS No. : 207556-62-5
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| Cat. No. : | HY-14293 |
| M.Wt: | 371.26 |
| Formula: | C15H20Cl2N6O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
NVP-DPP728 dihydrochloride is a potent, selective and orally active dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 11 nM. NVP-DPP728 dihydrochloride can be used for the research of diabetes mellitus[1][2].
IC50 & Target: Ki: 11 nM (DPP-IV) [1]
In Vitro: NVPDPP728 inhibits human and rat plasma DPP-IV (IC50s: 5-10 nM) with >15 000-fold selectivity relative to DPP-II and a range of proline-cleaving proteases[1].
In Vivo: NVP-DPP728 (3.72 mg/kg; p.o.) inhibits DPP-IV and improves insulin secretion and glucose tolerance, probably through augmentation of the effects of endogenous GLP-1[2].
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Inquiry Information- Product Name:
- NVP-DPP728 (dihydrochloride)
- Cat. No.:
- HY-14293
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