Saikosaponin A
CAS No. : 20736-09-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $35 | In-stock |
| 10mg | $60 | In-stock |
| 25mg | $125 | In-stock |
| 50mg | $210 | In-stock |
| 100mg | $360 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-N0246 |
| M.Wt: | 780.98 |
| Formula: | C42H68O13 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Saikosaponin A is the main active ingredient in Bupleurum chinense, which can regulate lipid metabolism and promote cholesterol efflux in early atherosclerosis. In addition, Saikosaponin A may also serve as a potential peroxisome proliferator-activated receptor γ (PPAR-γ) agonist, significantly promoting the expression of PPAR-γ. Saikosaponin A can be used in the study of hyperlipidemic pancreatitis[1][2][3].
In Vitro:Saikosaponin A (5-15 μM, 24 h) did not affect the viability of human osteoarthritis chondrocytes[1].
Saikosaponin A (5-15 μM, 24 h) inhibits IL-1β (HY-P73149)-induced NO and PGE2 production and NF-κB activation[1].
Saikosaponin A (5-15 μM, 24 h) up-regulates the expression of LXRα in a dose-dependent manner[1].
In Vivo:Saikosaponin A (1-10 mg/kg, i.p, 7 d) attenuates the morphological changes in the small intestine induced by 5-FU[2].
Saikosaponin-A (1-10 mg/kg, i.p, 7 d) enhances the decrease of antioxidant enzymes in intestinal tissue caused by 5-FU[2].
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