Guanosine 5'-triphosphate (trisodium salt hydrate)

Guanosine 5'-triphosphate (5'-GTP) trisodium salt hydrate is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt hydrate can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt hydrate holds promise for research in biosynthesis and skeletal muscle regeneration^[1]. In Vitro:Guanosine-5'-triphosphate disodium salt (500 μM, 24 h) hydrate significantly upregulates the expression of miR133a, miR133b, and the myogenic regulatory factor Myogenin in differentiated human myogenic precursor cells (MPCs)^[1].
Guanosine-5'-triphosphate disodium salt (500 μM, 24 h) hydrate can induce the release of exosomes from human myogenic precursor cells^[1].