Sudemycin K
CAS No. : 2071636-70-7
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| Cat. No. : | HY-122637 |
| M.Wt: | 486.69 |
| Formula: | C29H46N2O4 |
| Purity: | >98 % |
| Solubility: |
Sudemycin K is a selective splicing inhibitor targeting SF3B1. Sudemycin K blocks U2 snRNP recognition of branch point sequences in pre-mRNA, inducing tumor-specific splicing deregulation and apoptosis. Sudemycin K is promising for research of SF3B1-mutated malignancies such as chronic lymphocytic leukemia (CLL) and myelodysplastic syndromes (MDS)[1].
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