Niraxostat
CAS No. : 206884-98-2
(Synonyms: Y-700; Piraxostat)
| Size | Price | Stock |
|---|---|---|
| 1mg | $155 | In-stock |
| 5mg | $316 | In-stock |
| 10mg | $493 | In-stock |
| 25mg | $788 | In-stock |
| 50mg | $1120 | In-stock |
| 100mg | $1490 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-14669 |
| M.Wt: | 299.32 |
| Formula: | C16H17N3O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Niraxostat (Y-700; Piraxostat) is an orally active xanthine oxidoreductase (XOR) inhibitor used in the study of hyperuricemia and other diseases in which XOR may be involved[1].
In Vivo:Niraxostat (Y-700; 1 mg/kg) has high oral bioavailability (84.1%) and is almost not excreted through the kidneys. It is mainly eliminated through the liver[1].
Niraxostat (Y- 700; 1-10 mg/kg; oral; single dose) dose-dependently reduces plasma urate levels in oxonate-treated rats [1].
Niraxostat (Y-700 ; 0.3-3 mg/kg; Oral; Single dose) In normal rats, dose-dependently reduces urinary excretion of urate and allantoin while increasing excretion of hypoxanthine and xanthine [1].
Pharmacokinetic Analysis of Niraxostat (Y-700) in normal rats[1]
| Route | Dose (mg/kg) | tmax (h) | Cmax (μg/ml) | AUC0-∞ (μg/h/ml) | t1/2 (h) |
| PO | 0.3 | 0.5 | 0.43 | 2.07 | 5.0 |
| PO | 1 | 0.3 | 1.8 | 7.01 | 3.2 |
| PO | 3 | 0.5 | 6.49 | 30.31 | 2.7 |
| IV | 1 | / | 3.97 | 8.34 | 2.5 |
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