A1874
CAS No. : 2064292-12-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $250 | In-stock |
| 10mg | $450 | In-stock |
| 25mg | $750 | In-stock |
| 50mg | $1350 | In-stock |
| 100mg | $2180 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-114305 |
| M.Wt: | 1173.59 |
| Formula: | C58H62Cl3F2N9O7S |
| Purity: | >98 % |
| Solubility: | DMSO : 150 mg/mL (ultrasonic) |
A1874 is a nutlin-based (MDM2 ligand) and BRD4-degrading PROTAC with a DC50 of 32 nM (induce BRD4 degradation in cells). Effective in inhibiting many cancer cell lines proliferation[1].
IC50 & Target:DC50: 32 nM (induce BRD4 degradation in cells)[1].
In Vitro: Treatment of HCT116 cells of A1874 (0-10 μM, 24 hours) induces a dose-dependent knockdown of BRD4 levels, with near-maximum knockdown by 100 nmol/L and a maximum degradation (Dmax) of BRD4 of 98% of the levels in control (0.1% DMSO-treated) cells[1].
Treatment of HCT116 cells of A1874 (0-10 μM, 24 hours) increases p53 levels in the HCT116 cells and showed dose-dependent p53 stabilization[1].
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