Darunavir


CAS No. : 206361-99-1

(Synonyms: TMC114; UIC-94017)

206361-99-1
Price and Availability of CAS No. : 206361-99-1
Size Price Stock
5mg $40 In-stock
10mg $60 In-stock
25mg $90 In-stock
50mg $140 In-stock
100mg $210 In-stock
500mg $420 In-stock
1g $630 In-stock
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Cat. No. : HY-17040
M.Wt: 547.66
Formula: C27H37N3O7S
Purity: >98 %
Solubility: DMSO : ≥ 100 mg/mL
Introduction of 206361-99-1 :

Darunavir (TMC114), an orally active next generation HIV protease inhibitor, has a similar antiviral activity against the mutant and the wild-type viruses. Darunavir (TMC114) is potent against laboratory HIV-1 strains and primary clinical isolates (IC50 = 0.003 μM; IC90 = 0.009 μM) with minimal cytotoxicity[1][2]. In Vitro: Darunavir (TMC114, 1a) has a stability comparable to other protease inhibitors[1].
Darunavir (TMC114, UIC-94017) blocks the infectivity and replication of each of HIV-1NL4-3 variants exposed to and selected for resistance to Ro 31-8959, MK-639, AG1341, or ABT 538 at concentrations up to 5 μM (IC50s, 0.003 to 0.029 μM), although it was less active against HIV-1NL4-3 variants selected for resistance to VX-478 (IC50, 0.22 μM)[2].

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