| Size | Price | Stock |
|---|---|---|
| 5mg | $40 | In-stock |
| 10mg | $60 | In-stock |
| 25mg | $90 | In-stock |
| 50mg | $140 | In-stock |
| 100mg | $210 | In-stock |
| 500mg | $420 | In-stock |
| 1g | $630 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
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Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-17040 |
| M.Wt: | 547.66 |
| Formula: | C27H37N3O7S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Darunavir (TMC114), an orally active next generation HIV protease inhibitor, has a similar antiviral activity against the mutant and the wild-type viruses. Darunavir (TMC114) is potent against laboratory HIV-1 strains and primary clinical isolates (IC50 = 0.003 μM; IC90 = 0.009 μM) with minimal cytotoxicity[1][2].
In Vitro: Darunavir (TMC114, 1a) has a stability comparable to other protease inhibitors[1].
Darunavir (TMC114, UIC-94017) blocks the infectivity and replication of each of HIV-1NL4-3 variants exposed to and selected for resistance to Ro 31-8959, MK-639, AG1341, or ABT 538 at concentrations up to 5 μM (IC50s, 0.003 to 0.029 μM), although it was less active against HIV-1NL4-3 variants selected for resistance to VX-478 (IC50, 0.22 μM)[2].
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