TBK1/IKKε-IN-1
CAS No. : 2058264-32-5
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| Cat. No. : | HY-U00457 |
| M.Wt: | 498.53 |
| Formula: | C28H26N4O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
TBK1/IKKε-IN-1 is a dual TBK1 and IKKε inhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, has IC50s of <100 nM. IC50 & Target: IC50: <100 nM (TBK1), <100 nM (IKKε)[1] In Vitro: IKKε and TBK1 are serine/threonine kinases which are highly homologous to one another and other IkB kinases (IKK-α and IKK-β). The two kinases play an integral role in the innate immune system. Double-stranded RNA viruses are recognised by the Toll-like receptors 3 and 4 and the RNA helicases RIG-I and MDA-5 and result in activation of the TRIF-TBK1/IKKε-IRF3 signalling cascade, which results in a type I interferon response[1].
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