PF-06445974
CAS No. : 2055776-17-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $250 | In-stock |
| 10mg | $400 | In-stock |
| 25mg | $850 | In-stock |
| 50mg | $1350 | In-stock |
| 100mg | $1950 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-119190 |
| M.Wt: | 346.36 |
| Formula: | C20H15FN4O |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic;warming;heat to 60°C) |
PF-06445974, a promising positron emission tomography (PET) lead, has exquisite potency at PDE4B with an IC50 <1 nM. The IC50 values are 36, 4.7 and 17 nM for PDE4D, PDE4A and PDE4C, respectively. PF-06445974 has good selectivity over PDE4D, excellent brain permeability, and a high level of specific binding in the "cold tracer" study[1]. In Vitro: PF-06445974 demonstrates minimal off-target activities in broad-spectrum selectivity panels, with only weak µM activities at PDE10 (IC50=2290 nM), PDE5A (IC50=4640 nM) and GABAA (Ki=3850 nM)[1]. In Vivo: PF-06445974 exhibits high central nervous system (CNS) PET MPO score (4.0). PF-06445974 is a promising radiotracer lead for specific binding assessment. Neuropharmacokinetic study in rats (0.1 mg/kg, IV) confirms high brain permeability with a total brain to plasma ratio of 0.76, corresponding to a free brain to plasma ratio of 0.70[1].
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Inquiry Information- Product Name:
- PF-06445974
- Cat. No.:
- HY-119190
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