SHP394
CAS No. : 2055757-40-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $650 | In-stock |
| 10mg | $950 | In-stock |
| 25mg | $1900 | In-stock |
| 50mg | $3050 | In-stock |
| 100mg | $4850 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-114397 |
| M.Wt: | 470.51 |
| Formula: | C20H25F3N6O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 24 mg/mL (ultrasonic) |
SHP394 is an orally active, selective and allosteric inhibitor of SHP2, with an IC50 of 23 nM[1].
IC50 & Target:IC50: 23 nM (SHP2)[1]
In Vitro: SHP394 inhibits Caco-2 cells proliferation with the IC50 of 297 nM[1].
SHP394 exhibits antiproliferation activity against the Detroit-562 pharyngeal carcinoma cell line in vitro (IC50= 1.38 μM) [1].
SHP394 decreases p-ERK with an IC50 of 18 nM KYSE520 cells[1].
In Vivo: SHP394 (20-80 mg/kg; oral gavage; twice daily) dose-dependent reduces tumor volume[1].
SHP394 (80 mg/kg; oral gavage; twice daily) causes tumor 34% regression and reduces mouse host bodyweight after dosing for 14 days[1].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- SHP394
- Cat. No.:
- HY-114397
- Quantity:
Your information is safe with us.