(R)-KT109
CAS No. : 2055172-60-4
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|---|---|---|
| 500μg | $242 | Get quote |
| 1mg | $387 | Get quote |
| 5 mg | Get quote | |
| 10 mg | Get quote | |
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| Cat. No. : | HY-126031 |
| M.Wt: | 422.52 |
| Formula: | C27H26N4O |
| Purity: | >98 % |
| Solubility: |
(R)-KT109 is a peripherally restricted serine hydrolase inhibitor that cannot cross the blood-brain barrier. (R)-KT109 irreversibly inhibits ABHD6, DAGLα and DAGLβ via carbamoylation of the active-site serine. (R)-KT109 exerts selective inhibitory effects on serine hydrolases in mouse brains, with pIC50 values of 8.6, 9.1 and 8.2 against human ABHD6, DAGLα and DAGLβ, respectively. (R)-KT109 effectively reduces the levels of 2-arachidonoylglycerol, arachidonic acid, eicosanoids and TNF-α. (R)-KT109 is widely used in studies of metabolic syndrome-related diseases and neuroinflammation[1][2][3].
In Vitro:(R)-KT109 (0.1-1000 nM) selectively inhibits ABHD6 in mouse brain membrane proteome at concentrations ranging from 0.1 to 1000 nM[1].
(R)-KT109 (10 μM; 30 min) inhibits 99% of endogenous DAGLα and 95% of endogenous ABHD6 in mouse brain membrane proteome[3].
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