BU224 (hydrochloride)
CAS No. : 205437-64-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $58 | In-stock |
| 10mg | $88 | In-stock |
| 25mg | $190 | In-stock |
| 50mg | $305 | In-stock |
| 100mg | $440 | In-stock |
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| Cat. No. : | HY-101170 |
| M.Wt: | 233.70 |
| Formula: | C12H12ClN3 |
| Purity: | >98 % |
| Solubility: | DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C) |
BU224 hydrochloride is a selective and high affinity imidazoline I2 receptor ligand, with a Ki of 2.1 nM. BU224 hydrochloride is sometimes used as an I2 receptor antagonist. BU224 hydrochloride exerts neuroprotective effects, with anti-inflammatory and anti-apoptotic properties. BU224 hydrochloride improves memory in 5XFAD mice, enlarging dendritic spines and reducing Aβ-induced changes in NMDARs. BU224 hydrochloride can be used for Alzheimer's disease research[1][2][3].
IC50 & Target: Ki: 2.1 nM (I2)[1]
In Vivo: BU224 hydrochloride (5 mg/kg, IP, twice a day for 10 days) improves behavioural performance and memory function in 5XFAD mice[1].
BU224 hydrochloride (5 mg/kg, IP, twice a day for 10 days) reduces levels of the microglial marker Iba1 and pro-inflammatory cytokines IL-1β and TNF-α and increased the expression of astrocytic marker GFAP in 5XFAD mice[1].
BU224 hydrochloride (10 mg/kg, IP, once) reduces immobility of rats in the FST (forced swim test), indicative of antidepressant-like activity[2].
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