Amifostine
CAS No. : 20537-88-6
(Synonyms: WR2721)
| Size | Price | Stock |
|---|---|---|
| 5mg | $41 | In-stock |
| 10mg | $65 | In-stock |
| 25mg | $110 | In-stock |
| 50mg | $154 | In-stock |
| 100mg | $215 | In-stock |
| 200mg | $300 | In-stock |
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| 1 g | Get quote | |
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| Cat. No. : | HY-B0639 |
| M.Wt: | 214.22 |
| Formula: | C5H15N2O3PS |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic);DMSO : < 1 mg/mL (ultrasonic) |
Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine protects cells from damage by scavenging oxygen-derived free radicals. Amifostine reduces renal toxicity and has antiangiogenic action[1][2][3][4].
In Vitro: Amifostine (0.78125-100 μM, 24 h) reduces tert-Butyl hydroperoxide (TBHP)-induced cell damage in a dose-dependent manner and significantly reduces H9c2 cells apoptosis at a concentration of 100 μM[5].
In Vivo: Amifostine (i.v., 400 mg/kg, 4 h) has a protective effect against myocardial I/R injury in male C57BL/6 mice[5].
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