DL-TBOA
CAS No. : 205309-81-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $190 | In-stock |
| 10mg | $280 | In-stock |
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| Cat. No. : | HY-107522 |
| M.Wt: | 239.23 |
| Formula: | C11H13NO5 |
| Purity: | >98 % |
| Solubility: | DMSO : 200 mg/mL (ultrasonic);H2O : 5 mg/mL (ultrasonic;warming;heat to 60°C) |
DL-TBOA is a potent non-transportable inhibitor of excitatory amino acid transporters with IC50s of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively. DL-TBOA inhibits the uptake of [14C]glutamate in COS-1 cells expressing the human EAAT1 and EAAT2 with Ki valuesof 42 μM and 5.7 μM, respectively. DL-TBOA blocks EAAT4 and EAAT5 in a competitive manner with Ki values of 4.4 μM and 3.2 μM, respectively[1][2][3].
IC50 & Target:IC50: 70 μM (EAAT1), 6 μM (EAAT2) and 6 μM (EAAT3); Ki: 42 μM (human EAAT1), 5.7 μM (human EAAT2), 4.4 μM (EAAT4) and 3.2 μM (EAAT5)[1][2][3]
In Vitro:DL-TBOA (70-350 μM; 48 hours; HCT116 and LoVo cell lines) treatment concentration-dependently enhances SN38-induced loss of viability. DL-TBOA reversed Oxaliplatin-induced loss of viability[4].
DL-TBOA (350 μM; 24 hours; HCT116 and LoVo cell lines) treatment decreases p53 induction by SN38 and oxaliplatin[4].
In Vivo:DL-TBOA (10 nmol; i.c.v., rats) significantly facilitates the expression of naloxone-precipitated somatic signs and conditioned place aversion[5].
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