2614W94
CAS No. : 205187-35-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $230 | In-stock |
| 10mg | $380 | In-stock |
| 25mg | $798 | In-stock |
| 50mg | $1275 | In-stock |
| 100mg | $2040 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-101578 |
| M.Wt: | 344.31 |
| Formula: | C15H11F3O4S |
| Purity: | >98 % |
| Solubility: |
2614W94 is a selective, reversible and orally active monoamine oxidase-A (MAO-A) inhibitor with an IC50 of 5 nM and a Ki of 1.6 nM. 2614W94 shows no significant inhibition of MAO-B. 2614W94 has antidepressant and anxiolytic effects[1].
IC50 & Target:IC50: 5 nM (Monoamine Oxidase)[1]
Ki: 1.6 nM (Monoamine Oxidase)[1]
In Vitro:2614W94 shows potent inhibitory activity against MAO-A, but shows no inhibition of MAO-B at 30 nM[1].
In Vivo:2614W94 (5 mg/kg, p.o.) produces selective inhibition of MAO-A in brains and livers of rats. 2614W94 (5 mg/kg, p.o.) also causes an elevation of neurotransmitter amines in brain, inparticular serotonin and norepinephrine, with a concomitant decrease in their oxidized metabolites. 2614W94 (0.5, 1, 2 mg/kg, p.o.) potentiates 5-hydroxytryptophan-induced head twitches in rats in a dose-dependent manner, with an extrapolated ED50 of 1.1 mg/kg[1].
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- Cat. No.:
- HY-101578
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