P-gp inhibitor 1
CAS No. : 2050747-49-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $76 | In-stock |
| 25mg | $160 | In-stock |
| 50mg | $240 | In-stock |
| 100mg | $360 | In-stock |
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| Cat. No. : | HY-101791 |
| M.Wt: | 517.62 |
| Formula: | C32H31N5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 70°C) |
P-gp inhibitor 1 is a novel inhibitor reversing P-glycoprotein-mediated multidrug resistance. IC50 & Target: P-glycoprotein[1] In Vitro: P-gp inhibitor 1 (12k) possesses high potency (EC50=57.9±3.5 nM), low cytotoxicity, and long duration of activity in reversing doxorubicin (DOX) resistance in K562/A02 cells (1 μM, 80 minutes)[1].
P-gp inhibitor 1 also boosts the potency of other MDR-related cytotoxic agents with different structures, increases accumulation of DOX, blocks Pgp-mediated Rh123 efflux, and suppresses P-gp ATPase activity in K562/A02 MDR cells (0.1, 1, 5 μM, 1 hour)[1].
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