Diallyl Trisulfide

Diallyl Trisulfide is an orally active anticancer agent that can be isolated from garlic. Diallyl Trisulfide has the ability to induce apoptosis and exhibits anticancer, anti-inflammatory, antioxidant, and antibacterial activities. Diallyl Trisulfide can be used to study a variety of cancers, including liver, colon and prostate cancer^[1][2][3][4]. IC50 & Target:Penicillium expansum (MFC₉₉ value: ≤ 90)^[1];
Apoptosis^[1];
Reactive oxygen species (ROS)^[1] In Vitro:Diallyl Trisulfide (25-100 μM; 24-72 h) induces apoptosis and inhibits cell proliferation in A549 cells, exhibiting anticancer activity^[1].
Diallyl Trisulfide (5-10 μM; 1 h) significantly inhibits naphthalene (20 μM)-stimulated ROS generation and reduces the levels of inflammatory factors IL-6, TNF-α, and IL-8 by increasing superoxide dismutase (SOD) activity, thereby possessing antioxidant and anti-inflammatory activities^[2].
Diallyl Trisulfide (93.75-375 µM; 24 h) attenuates H9N2 avian influenza virus (AIV) infection in human lung A549 epithelial cells, demonstrating antiviral activity^[3].
Diallyl Trisulfide inhibits the growth of Penicillium expansum with antifungal activity (minimum fungicidal concentration (MFC)₉₉ value: ≤ 90 μg/mL)^[4].
In Vivo:Diallyl Trisulfide (6 μM/animal; Oral gavage, every other day for 30 days) inhibits tumor growth and exhibits anticancer activity in BALB/c nude mice^[1].
Diallyl Trisulfide (20-80 mg/kg; Oral gavage, single dose) demonstrates antioxidant and anti-inflammatory activities in Kunming mice induced by naphthalene (100 mg/kg; orally, single dose)^[2].
Diallyl Trisulfide (30 mg/kg; intraperitoneal injection; once daily for 2 weeks) reduces lung edema and inflammation caused by H9N2 AIV infection in BABL/c mice, exhibiting antiviral activity^[3].