Nemifitide (diTFA)
CAS No. : 204992-09-6
(Synonyms: INN 00835 (diTFA))
| Size | Price | Stock |
|---|---|---|
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| 10mg | $450 | In-stock |
| 50mg | $1650 | In-stock |
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| Cat. No. : | HY-105077A |
| M.Wt: | 922.80 |
| Formula: | C37H45F7N10O10 |
| Purity: | >98 % |
| Solubility: | H2O : 250 mg/mL (ultrasonic) |
Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action[1]. Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF)[2]. Nemifitide diTFA can cross the blood-brain barrier[3].
In Vitro: Nemifitide diTFA (INN 00835 diTFA) and its active metabolite (M1) bind at micromolar concentrations to several receptors including the 5-HT2A, 5-HT2C, melanocortin MC4, MC5 and bombesin[3].
In Vivo: Nemifitide diTFA (INN 00835 diTFA; 0.3 mg/kg; IP; daily; for 14 days) significantly increases swimming in the FSL rats after just 5 days of treatment and has long-lasting effect[2].
Nemifitide diTFA (0.0125-15.0 mg/kg) significantly increases swimming in the FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses but not at intermediate (0.4-2.4 mg/kg) doses[2].
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