BIIL-260
CAS No. : 204974-93-6
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| Cat. No. : | HY-114641 |
| M.Wt: | 466.57 |
| Formula: | C30H30N2O3 |
| Purity: | >98 % |
| Solubility: |
BIIL-260 is a potent and long-acting orally active leukotriene B(4) receptor LTB4 antagonist, with anti-inflammatory activity. BIIL-260 interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB4 receptor on isolated human neutrophil cell membranes with the Ki value of 1.7 nM[1]. IC50 & Target:Ki: 1.7 nM (LTB4 receptor)[1] In Vitro:BIIL-260 potently inhibits LTB4-induced intracellular Ca2+ release in human neutrophils with the IC50 value of 0.82 nM.
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