Indibulin
CAS No. : 204205-90-3
(Synonyms: ZIO 301; D 24851)
| Size | Price | Stock |
|---|---|---|
| 5mg | $45 | In-stock |
| 10mg | $70 | In-stock |
| 25mg | $140 | In-stock |
| 50mg | $230 | In-stock |
| 100mg | $365 | In-stock |
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| Cat. No. : | HY-13649 |
| M.Wt: | 389.83 |
| Formula: | C22H16ClN3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Indibulin (ZIO 301), an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis[1].
IC50 & Target: Tubulin[1]
In Vitro: Indibulin (300-2100 nM; 48?hours) inhibits the proliferation of MCF-7 cells with an IC50 of 150?nM[1].
Indibulin (300, 600 nM; 48?hours) blockes the cells in the G2/M phase indicating that indibulin blockes the progression of the cell cycle at mitosis[1].
Indibulin (150-600 nM; 24?hours) induces apoptosis in MCF-7 cells[1].
Indibulin (150-600 nM; 48?hours) with 300 and 600?nM generates cleaved fragments of PARP protein the treatment of MCF-7 cells[1].
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