LLY-283
CAS No. : 2040291-27-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $99 | In-stock |
| 10mg | $165 | In-stock |
| 25mg | $330 | In-stock |
| 50mg | $594 | In-stock |
| 100mg | $1034 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-107777 |
| M.Wt: | 342.35 |
| Formula: | C17H18N4O4 |
| Purity: | >98 % |
| Solubility: | H2O : 3.57 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : 100 mg/mL (ultrasonic) |
LLY-283 is a potent, selective and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM and a Kd of 6 nM for PRMT5:MEP50 complex, and shows antitumor activity.
IC50 & Target: IC50: 22 nM (PRMT5:MEP50)[1]
Ki: 6 nM (PRMT5:MEP50)[1]
In Vitro: LLY-283 is a potent, oral and selective arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM in vitro and 25 nM in cells, as well as a Kd of 6 nM for PRMT5:MEP50 complex in vitro; LLY-283 inhibits the proliferation of A375 cell with an IC50 of 46 nM[1].
In Vivo: LLY-283 (20 mg/kg; p.o., QD (once a day)) causes a significant inhibition on tumor growth in mice bearing A375 cells after treatment for 28 days[1].
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