Istaroxime
CAS No. : 203737-93-3
(Synonyms: PST2744)
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| Cat. No. : | HY-15718 |
| M.Wt: | 360.49 |
| Formula: | C21H32N2O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Istaroxime (PST2744) is a potent inhibitor of Na+,K+-ATPase with IC50 of 0.11 μM. IC50 & Target: IC50: 0.11 μM (Na+,K+-ATPase)[1] In Vitro: Istaroxime acting as a positive inotropic compound through the inhibition of the Na+,K+-ATPase[2]. Istaroxime (PST2744) inhibits the Na+/K+-ATPase activity from dog kidney with an IC50 value of 0.43 ± 0.15 μM. Inhibition of Na+/K+-ATPase activity in preparations from guinea pig kidney yielded potencies of 8.5 μM for PST2744[3]. In Vivo: Istaroxime (PST2744) induces a progressive increase in +dP/dtmax throughout the infusion that reaches 80% (ED80) at the cumulative dose of 1.89±0.37 mg/kg and a peak of 140±3.5% at the dose (EDmax) of 4.88±0.6 mg/kg[3].
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