Porcn-IN-1
CAS No. : 2036044-77-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $125 | In-stock |
| 10mg | $200 | In-stock |
| 25mg | $360 | In-stock |
| 50mg | $540 | In-stock |
| 100mg | $700 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-111472 |
| M.Wt: | 410.44 |
| Formula: | C25H19FN4O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Porcn-IN-1 is potent porcupine inhibitor with an IC50 of 0.5±0.2 nM. IC50 & Target: IC50: 0.5±0.2 nM (Porcupine inhibitor)[1] In Vitro: Porcupine is an enzyme that catalyses the addition of palmitoleate to a serine residue in Wnt proteins, a process which is required for the secretion of Wnt proteins. Porcupine-IN-1 is as potent as the clinical compound LGK974 in a cell based STF reporter gene assay. Porcn-IN-1 potently inhibits the secretion of Wnt3A, therefore is confirmed to be a porcupine inhibitor[1]. In Vivo: Porcn-IN-1 demonstrates moderate clearance under the treatment of human liver microsomes (57 mL/min/kg) and rat liver microsomes (24 mL/min/kg). It exhibits high clearance when treated with mouse microsomes (109 mL/min/kg)[1].
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