(-)-Maackiain
CAS No. : 2035-15-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $65 | In-stock |
| 5mg | $138 | In-stock |
| 10mg | $235 | In-stock |
| 20mg | $400 | In-stock |
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| Cat. No. : | HY-N6051 |
| M.Wt: | 284.27 |
| Formula: | C16H12O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
(-)-Maackiain is a pterocarpan phytoalexin produced from Sophora flavescens. (-)-Maackiain is toxic to several genera of fungal pathogens of legume and non legume hosts. (-)-Maackiain enhances the activation of NLRP3 inflammasome, inhibits the activation of NF-κB pathway, exhibiting thereby immunostimulatory and anti-inflammatory activities. (-)-Maackiain is orally active[1][2].
In Vitro:(-)-Maackiain (0-30 µM, 24 h) inhibits PMA (HY-18739)-induced histamine H1 receptor (H1R) expression in HeLa cells, inhibits DNP-HSA (antigen)-stimulated IL-4 gene expression in RBL-2H3 cells[3].
(-)-Maackiain (0-30 µM, 24 h) inhibits PMA -induced PKCδ phosphorylation at tyrosine 311 and prevents PKCδ from transferring to the Golgi apparatus[3].
In Vivo:(-)-Maackiain (5-20 mg/kg, po, once daily for 3 weeks) exhibits antiallergic activity in TDI-induced nasal hypersensitivity mouse model[3].
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