Methiocarb

Methiocarb (Mercaptodimethur) is an orally active carbamate insecticide. Methiocarb exerts dose-dependent toxic effects on onions. In addition to inhibiting acetylcholinesterase to induce cholinergic excitation, Methiocarb can induce lipid peroxidation in liver, kidney, brain and testicular tissues and alter reduced glutathione levels by generating ROS. Methiocarb can be used for agricultural pest control and research on oxidative stress-related cellular damage in mammals^[1][2]. In Vitro:Methiocarb (2.5-7.5 mg/L; 72 h) exerts dose-dependent toxic effects on Allium cepa L. bulbs, including reducing rooting rate, root length and weight gain rate, increasing micronucleus rate, chromosome damage degree and MDA level, decreasing mitotic index, and elevating SOD and CAT activities, with the strongest effects observed at the concentration of 7.5 mg/L^[1]. In Vivo:Methiocarb (2-25 mg/kg; i.g.; once daily; 1-28 days) induces lipid peroxidation in the liver, kidney, brain and testis of rats, and disrupts their glutathione levels^[2].