ZM223
CAS No. : 2031177-48-5
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| Cat. No. : | HY-101790 |
| M.Wt: | 502.53 |
| Formula: | C23H17F3N4O2S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 83.33 mg/mL (ultrasonic) |
ZM223 is a potent non-covalent NEDD8 activating enzyme (NAE) inhibitor, orally active[1]. IC50 & Target: NEDD8 activating enzyme (NAE)[1] In Vitro: ZM223 (0.1-1 μM; 4 hours) inhibits both HCT-116 and U-2OS cancer cells with IC50s of 100 and 122 nM, respectively[1]. ZM223 (0.1-1 μM; 4 hours) causes a dose-response decrease in the level of NEDD8 and accumulation of the UBC12 protein, indicating the decrease of the subsequent NEDD8-UBC12 complex[1].
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