TAM-16
CAS No. : 2030241-59-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $135 | In-stock |
| 10mg | $215 | In-stock |
| 25mg | $430 | In-stock |
| 50mg | $688 | In-stock |
| 100mg | $1100 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-116838 |
| M.Wt: | 380.44 |
| Formula: | C22H24N2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
TAM-16 is a potent and orally active polyketide synthase 13 (Pks13) inhibitor with an IC50 value of 0.32 μM. TAM-16 has promising activity against Mycobacterium tuberculosis. TAM-16 inhibits hERG cardiac ion channel[1][2].
In Vitro:TAM-16 (compound 1) inhibits the growth of M. tuberculosis strain H37Rv with an IC50 value of 0.08 μM[1].
TAM-16 (0-10 μM) inhibits Mycobacterium tuberculosis by targeting Pks13[1].
In Vivo:TAM-16 (compound 1; 200 mg/kg; p.o.; daily, for 14 days) prevents the development of characteristic lung lesions in murine TB infection models[2].
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