Orexin B, rat, mouse
CAS No. : 202801-92-1
(Synonyms: Rat orexin B; Orexin B (mouse))
| Size | Price | Stock |
|---|---|---|
| 1mg | $110 | In-stock |
| 5mg | $275 | In-stock |
| 10mg | $420 | In-stock |
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| Cat. No. : | HY-P1349 |
| M.Wt: | 2936.40 |
| Formula: | C126H215N45O34S |
| Purity: | >98 % |
| Solubility: | H2O : 16.67 mg/mL (ultrasonic) |
Orexin B, rat, mouse (Rat orexin B) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively. IC50 & Target: Ki: 420 nM (OX1), 36 nM (OX2)[1] In Vitro: OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC50 of 36 nM in the binding assay and an EC50 of 60 nM in the [Ca2+]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC50 in the competitive binding assay and the EC50 in the [Ca2+]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively[2]. In Vivo: Orexin-B modulates the activity of rod bipolar cells (RBCs) located in the outer retina of rat. Intravitreal injection of orexin-B increased the amplitude of the scotopic electroretinographic b-wave, a reflection of RBC activity, recorded in vivo[4].
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