RIG 200
CAS No. : 202656-49-3
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| Cat. No. : | HY-107000 |
| M.Wt: | 549.55 |
| Formula: | C21H31N3O12S |
| Purity: | >98 % |
| Solubility: |
RIG 200 is an S-nitrosothiol nitric oxide (NO) donor. RIG 200 releases NO through decomposition, activating guanylate cyclase (sGCM) in vascular smooth muscle cells, increasing cGMP levels, and leading to vasodilation. RIG 200 significantly inhibits Collagen (HY-NP003)-induced platelet aggregation in platelet-rich plasma (PRP). RIG 200 may be used in research on antithrombus[1][2][3].
In Vitro:RIG 200 (4-100 μM) inhibits platelet aggregation induced by Collagen with an IC₅₀ of 0.8 μM in platelet-rich plasma (PRP) but is impossible to inhibit platelet aggregation in whole blood (WB)[1].
RIG 200 (10 μM) significantly increases the cGMP level of platelets in PRP[1].
RIG 200 (0.01-10 μM, 30 min) continuously inhibits the contraction effect of isolated vascular rings, and its dilating effect can significantly persist after elution[2].
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