FR194921
CAS No. : 202646-80-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $283 | In-stock |
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| 50 mg | Get quote | |
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| Cat. No. : | HY-116800 |
| M.Wt: | 385.46 |
| Formula: | C23H23N5O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
FR194921 is a potent, selective and orally active and cross the blood-brain barrier Adenosine A1 antagonist with Ki value of 6.6, 5400 nM for A1, A2A, respectively. FR194921 shows cognitive-enhancing and anxiolytic activity[1][2].
In Vivo:FR194921 (32 mg/kg; p.o.) shows good oral bioavailability with AUC of 6.91 µg·h/mL, Cmax of 2.13 µg/mL and Tmax OF 0.63 h, BA of 60.6% in rats[1].
FR194921 (0.032, 0.1, 0.32 mg/kg; p.o.) dose-dependently attenuates the hypolocomotion induced by CPA (HY-103181)[2].
FR194921 (0.1-10 mg/kg; i.p.) significantly ameliorates scopolamine (HY-N0296)-induced memory deficits[2].
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- FR194921
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