Ro 04-6790
CAS No. : 202466-68-0
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| Cat. No. : | HY-14335 |
| M.Wt: | 308.36 |
| Formula: | C12H16N6O2S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Ro 04-6790 is a potent, competitive and selective 5-HT6 receptor antagonist with pKi values of 7.26, 7.35 for rat and human 5-HT6 receptors, respectively. Ro 04-6790 has no affinity at other receptors[1]. In Vitro: Ro 04-6790 has over 100 fold selective for the 5-HT6 receptor compared to other receptor binding sites (IC50>10 μM)[1]. In Vivo: Ro 04-6790 (10 mg/kg, SC) produces a modest (50%) increase in ACh outflow in adult male Wistar rats of 250-300 g (this effect is not statistically different from the action of vehicle)[2].
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