Flucytosine
CAS No. : 2022-85-7
(Synonyms: 5-Fluorocytosine; NSC 103805; Ro 2-9915)
| Size | Price | Stock |
|---|---|---|
| 5g | $5 | In-stock |
| 100g | $26 | In-stock |
| 500g | $90 | In-stock |
| 1000g | $108 | In-stock |
| > 2 kg | Get quote | |
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| Cat. No. : | HY-B0139 |
| M.Wt: | 129.09 |
| Formula: | C4H4FN3O |
| Purity: | >98 % |
| Solubility: | H2O : 6.67 mg/mL (ultrasonic);DMSO : 16.67 mg/mL (ultrasonic) |
Flucytosine (5-Fluorocytosine) is an antifungal compound with oral activity. Flucytosine is a widely used cytotoxic drug that, after further metabolism, produces fluorinated ribonucleotides and deoxyribonucleotides, inhibits DNA and protein synthesis, and has multiple effects such as inhibiting candida and candida neoplasm infection and producies cytotoxicity to cancer cells[1][2][3].
In Vitro:Flucytosine transfected CD-gene hMSC (CD-hMSC) effectively converts 5-FC into 5-FU, showing anti-cancer therapeutic potential[2].
In Vivo:Flucytosine (500 mg/kg/ day, intravenous injection for 7 days) can effectively reduce tumor volume and weight in CD-hMSC mice[2].
Flucytosine (50, 75 mg/kg/ day, gavage, 3-30 days) combines with itraconazole (HY-17514) can effectively inhibit cryptococcus infection in hamsters[3].
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