PTAC (oxalate)
CAS No. : 201939-40-4
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| Cat. No. : | HY-107656 |
| M.Wt: | 359.46 |
| Formula: | C14H21N3O4S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
PTAC oxalate is a selective muscarinic receptor ligand. PTAC oxalate is an partial agonist of M2 and M4 but antagonist of M1, M3, and M5 (Ki values of 0.2-2.8 nM for hM1-5 in CHO cells). PTAC oxalate alleviates the mechanical allodynia on the neuropathic pain and has antidepression effects[1][2]. In Vivo:PTAC oxalate (0.01, 0.05 mg/kg; IP) alleviates the mechanical allodynia in 0.05 mg/kg. PTAC oxalate decreases the immobility time of mice from both the sham and nerve injury groups at the dose of 0.05 mg/kg, but not at the dose of 0.01 mg/kg[2].
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