Ombuoside

Ombuoside has antioxidant properties, inhibiting ROS production and apoptosis. Ombuoside exerts neuroprotective effects through the ERK-JNK-caspase-3 system. Ombuoside promotes Dopamine biosynthesis through TH and CREB activation. Ombuoside exhibits antimicrobial activity against several Gram-positive and Gram-negative bacteria, as well as Candida albicans^{[1][2][3][4][5]} In Vitro:Ombuoside (0-100 μM, 24-26 h) inhibits HEI-OC1 cells growth only treatment with 80 or 100 μM, increases the survival of Cisplatin (HY-17394)-treated HEI-OC1 cells, with the 30 μM dose demonstrating the most protective effect^[1].
Ombuoside (30 μM, 24 h) reduces Cisplatin-induced apoptosis, oxidative stress via the mitochondria-related apoptotic pathway in HEI-OC1 cells^[1].
Ombuoside (30 μM, 24 h) protects cochlear explants from Cisplatin-induced hair cell damage by inhibiting apoptosis^[1].
Ombuoside (1-100 μM, 1-72 h) reduces PC12 cells viability to 80.4% of the control level at 100 µM, increases the cell viability in L-DOPA (HY-N0304)- induced PC12 cells^[2].
Ombuoside (1-10 μM, 0-6 h) decreases phosphorylation of ERK1/2 and JNK1/2, the expression of cleaved-caspase-3, increases SOD activity in L-DOPA- induced PC12 cells^[2].
Ombuoside (1-10 μM, 0-24 h) increases Dopamine (HY-B0451) levels in a time- and dose-dependent manner, increases the phosphorylation of TH (Ser40) and CREB (Ser133) level in PC12 cells^[3].
In Vivo:Ombuoside (30 μM, 24 h) protects zebrafish hair cells from Cisplatin-induced damage^[1].