TPOP146
CAS No. : 2018300-62-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $105 | In-stock |
| 10mg | $180 | In-stock |
| 25mg | $310 | In-stock |
| 50mg | $480 | In-stock |
| 100mg | $800 | In-stock |
| 250mg | $1400 | In-stock |
| 500mg | $2330 | In-stock |
| 1 g | Get quote | |
| 5 g | Get quote | |
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| Cat. No. : | HY-100697 |
| M.Wt: | 481.58 |
| Formula: | C27H35N3O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 21.43 mg/mL (ultrasonic;warming;heat to 60°C) |
TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor with Kd values of 134 nM and 5.02 μM for CBP and BRD4. IC50 & Target: IC50: 134 nM (CBP); 5.02 μM (BRD4)[1] In Vitro: Exposure to 1 μM TPOP146 results in a significant decrease of recovery half-life that is comparable to the construct that contained the bromodomain inactivating mutation N1168F, demonstrating that TPOP146 targets the CBP bromodomain in the nucleus and is capable of competing with acetyl-lysine mediated interactions of the CBP bromodomain in cellular environments[1].
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