AZ13705339
CAS No. : 2016806-57-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $130 | In-stock |
| 25mg | $270 | In-stock |
| 50mg | $430 | In-stock |
| 100mg | $690 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-120940 |
| M.Wt: | 629.75 |
| Formula: | C33H36FN7O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
AZ13705339 is a highly potent and selective PAK1 inhibitor with IC50s of 0.33 nM and 59 nM for PAK1 and pPAK1, respectively. AZ13705339 has binding affinities to PAK1 and PAK2, with Kds of 0.28 nM and 0.32 nM, respectively. AZ13705339 can be used in the research of cancers[1].
In Vitro: AZ13705339 (1 μM) inhibits αIgM-controlled adhesion and not PMA-induced adhesion in Namalwa cells[2].
AZ13705339 (300 nM, 30 min) prevents Siglec-8 engagement-induced eosinophil death[3].
In Vivo: AZ13705339 (100 mg/kg, P.O.) has moderate clearance and oral Cmax of 7.7 μM in rats[1].
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