NAMI-A
CAS No. : 201653-76-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $210 | In-stock |
| 25mg | $420 | In-stock |
| 50mg | $672 | In-stock |
| 100mg | $1075 | In-stock |
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| Cat. No. : | HY-19376 |
| M.Wt: | 458.18 |
| Formula: | C5H10Cl4N2ORuS.C3H4N2.H |
| Purity: | >98 % |
| Solubility: | H2O : 8.28 mg/mL (ultrasonic;warming) |
NAMI-A is a ruthenium-based drug characterised by the selective activity against tumour metastases, inhibits the adhesion and migration. In vitro: NAMI-A can significantly affect tumor cells with metastatic ability. The half lifetime of NAMI-A elimination from the lungs is longer than for liver, kidney, and primary tumor. NAMI-A bound to collagen is active on tumor cells as shown in vitro by an invasion test, using a modified Boyden chamber and Matrigel, and it inhibits the matrix metallo-proteinases MMP-2 and MMP-9 at micromolar concentrations. [1] The ruthenium drug NAMI-A inhibits the adhesion and migration of colorectal cancer cells. NAMI-A decreases α5β1 integrin expression and FAK auto-phosphorylation on Tyr 397. [2] In vivo: The reference for NAMI-A is 35 mg/kg/day. [1]
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