(-)Clausenamide
CAS No. : 201529-58-0
| Size | Price | Stock |
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| 5mg | $1725 | In-stock |
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| Cat. No. : | HY-116753 |
| M.Wt: | 297.35 |
| Formula: | C18H19NO3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
(-)Clausenamide is an active alkaloid isolated from the leaves of Clausena lansium (Lour.) Skeels, and improves cognitive function in both normal physiological and pathological conditions. (-)Clausenamide inhibits β-amyloid (Aβ) toxicity, blocking neurofibrillary tangle formation by inhibiting the phosphorylation of tau protein. (-)Clausenamide exerts a significant neuroprotective activity against Aβ25-35. (-)Clausenamide can be used for researching Alzheimer's disease (AD)[1][2][3].
In Vitro: (-)Clausenamide (10 and 100 μM) reverses the overload in [Ca2+]i level stimulated by Aβ25-35, and reduces Aβ-mediated cell apoptosis in PC12 cells[3].
(-)Clausenamide (10 and 100 μM) inhibits the phosphorylation of p38 MAPK, down-regulates the expression of P53 and cleaved Caspase-3 and the ratio of Bax/Bcl-2, in Aβ25-35-treated PC12 cells[3].
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