Diosmetin-7-O-β-D-glucopyranoside

Diosmetin-7-O-β-D-glucopyranoside is a natural product that can be isolated from the flowers of Chrysanthemum morifolium. Diosmetin-7-O-β-D-glucopyranoside has potent antiviral and anti-inflammatory activities against SARS-CoV-2 both in vitro (IC₅₀ = 0.74 μM) and in vivo. Diosmetin-7-O-β-D-glucopyranoside has significant anti-thrombotic activity when combined with Pae and 5-HMF at a ratio of 3:4:3 in a zebrafish model^[1][2][3]. In Vitro:Diosmetin-7-O-β-D-glucopyranoside (Compound DG) (0-300 μM, 48 h) has strong antiviral activity against SARS-CoV-2 in BEAS-2B cells (IC₅₀ = 0.74 μM)^[3].
Diosmetin-7-O-β-D-glucopyranoside (12.5-100 μM) shows low cytotoxicity in mouse macrophage hACE2-expressing RAW264.7 cells^[3].
Diosmetin-7-O-β-D-glucopyranoside (0.625-2.5 μM) decreases the apoptotic rates of SARS-CoV-2-infected cells as well as viral loads in a concentration-dependent manner^[3].
Diosmetin-7-O-β-D-glucopyranoside (0.625-10 μM) sharply reduces the expression in wild-type YTHDF1-transfected H293T cells^[3]. In Vivo:Diosmetin-7-O-β-D-glucopyranoside (Compound DG) (25-100 mg/kg, i.p., 5 d) improves SARS-CoV-2-induced acute pneumonia in mice^[3].