Calcium dobesilate
CAS No. : 20123-80-2
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| Cat. No. : | HY-111603 |
| M.Wt: | 418.41 |
| Formula: | C12H10CaO10S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 150 mg/mL (ultrasonic);H2O : ≥ 100 mg/mL |
Calcium dobesilate is a vascular protector with oral activity that can clear hydroxyl free radicals, with an IC50 of 1.1 pM. Calcium dobesilate has antioxidant activity and helps to reduce oxidative stress and inflammation in the retinas of diabetic mice. Calcium dobesilate can be used to study chronic venous diseases, diabetic retinopathy, and the occurrence of hemorrhoids, among other conditions[1][2][3].
In Vitro:Calcium dobesilate (500 μM) significantly reduces the chemiluminescence of human PMN cells induced by platelet-activating factor (PAF) and decreases lipid peroxidation caused by oxygen free radicals in human red blood cell membranes[1].
Calcium dobesilate (5-10 mM) lowers MDA levels in human red blood cells[1].
Calcium dobesilate (0-10000 μM, for 5 days) at higher concentrations leads to a rapid decrease in live cells and an increase in the percentage of apoptotic cells[2].
In Vivo:Calcium dobesilate (200 mg/kg, once daily, for 15 days) exhibits antioxidant and anti-inflammatory activities and reduces biomarkers of oxidative stress in the retina of db/db mice[3].
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