MZP-55
CAS No. : 2010159-48-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $220 | In-stock |
| 5mg | $550 | In-stock |
| 10mg | $850 | In-stock |
| 25mg | $1600 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-112377 |
| M.Wt: | 1080.72 |
| Formula: | C57H70ClN7O10S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
MZP-55 is a PROTAC connected by ligands for von Hippel-Lindau and BRD3/4, with a Kd of 8 nM for Brd4BD2. IC50 & Target:Kd: 8 nM (Brd4BD2)[1] In Vitro: MZP-55 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 8 nM for Brd4BD2. MZP-55 binds to VHL-EloC-EloB protein (VCB) with a Kd of 105 ± 24 nM. MZP-55 shows an inhibitory activity against MV4;11 and HL60 cells, with pEC50s of 7.31 ± 0.03 and 6.57 ± 0.02, respectively[1].
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