OSIP-486823
CAS No. : 200803-37-8
(Synonyms: CP248)
| Size | Price | Stock |
|---|---|---|
| 1mg | $568 | In-stock |
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| Cat. No. : | HY-U00004 |
| M.Wt: | 473.54 |
| Formula: | C29H28FNO4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
OSIP-486823 is a novel microtubule-interfering agent with distinct biological effects on both protein kinase G (PKG) and microtubules. IC50 & Target: Microtubule[1] In Vitro: OSIP486823 inhibits growth and induce apoptosis in SW480 human colon cancer cells, with IC50 of 0.1 μM. OSIP-486823 (OSIP486823) causes depolymerization of microtubules in interphase cells, inhibit spindle formation in mitotic cells, and induce multinucleated cells. Exisulind and the potent synthetic derivative OSIP-486823 are members of a new class of drugs known as selective apoptotic antineoplastic drugs that target cyclic guanosine 3′,5′-monophosphate phosphodiesterases (cGMP-PDE). OSIP-486823 also disrupts microtubule polymerization, perturbs mitotic spindle function, and arrests cells in mitosis in human glioma cells[1].
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