CM-414
CAS No. : 2007971-51-7
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| Cat. No. : | HY-119316 |
| M.Wt: | 439.52 |
| Formula: | C23H29N5O4 |
| Purity: | >98 % |
| Solubility: |
CM-414 is a brain-penetrant phosphodiesterase 5 (PDE5) and HDAC inhibitor with IC50s of 60 nM, 91 nM, 310 nM, 322 nM and 490 nM for PDE5, HDAC6, HDAC1, HDAC3 and HDAC2, respectively. CM-414 diminishes brain Aβ and tau phosphorylation (pTau) level in Tg2576 mice. CM-414 can be used for the study of Alzheimer's disease (AD)[1][2]. In Vivo:CM-414 (compound 7) (40 mg/kg, intraperitoneal (i.p.)) induces AcH3K9 acetylation and CREB phosphorylation in the hippocampus and rescues long-term potentiation (LTP) in APP/PS1 mice[1].
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