Polyketomycin


CAS No. : 200625-47-4

200625-47-4
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Cat. No. : HY-106338
M.Wt: 864.84
Formula: C44H48O18
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 200625-47-4 :

Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities[1][2][3]. IC50 & Target:MIC: 0.025-0.2 µg/mL (Methicillin-resistant Staphylococcus aureus (MRSA))[1] In Vitro: Polyketomycin exhibits growth inhibition against L1210 leukemia, EL-4 leukemia, P388 leukemia, Ehrlich carcinoma, IMC carcinoma, colon 26 adnocarcinoma, Meth A fibrosarcoma, FS-3 fibrosarcoma and B16-BL10 melanoma with IC50 values of 3.3 μg/mL, 2.1 μg/mL, 5.2 μg/mL, 1 μg/mL, 0.9 μg/mL, 1.8 μg/mL, 2.4 μg/mL, 1.5 μg/mL and 1.6 μg/mL, respectively[1]. In Vivo: The acute toxicity (LD50, ip) of Polyketomycin in mice is estimated to be 6.25-12.5mg/kg[1].

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