3-Ethoxy-5,6-dibromosalicylaldehyde
CAS No. : 20041-64-9
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| Cat. No. : | HY-123996 |
| M.Wt: | 323.97 |
| Formula: | C9H8Br2O3 |
| Purity: | >98 % |
| Solubility: |
3-ethoxy-5,6-dibromosalicylaldehyde is a potent, non-competitive, selective IRE1 (including IRE1α) inhibitor (IC50s: ∼0.12 μM for hIRE1α-cyto; 6 μM for yeast Ire1). 3-ethoxy-5,6-dibromosalicylaldehyde inhibits XBP-1 splicing. 3-ethoxy-5,6-dibromosalicylaldehyde induces Apoptosis. 3-ethoxy-5,6-dibromosalicylaldehyde upregulates the mRNA expression level of TXNIP, while downregulating the expression level of TXN. 3-ethoxy-5,6-dibromosalicylaldehyde exhibits anticancer activity against pancreatic cancer. 3-ethoxy-5,6-dibromosalicylaldehyde significantly inhibits chikungunya virus replication[1][2][3]. IC50 & Target:IC50s: ∼0.12 μM for hIRE1α-cyto; 6 μM for yeast Ire1[1]
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