(R)-GNE-140
CAS No. : 2003234-63-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $200 | In-stock |
| 10mg | $278 | In-stock |
| 25mg | $460 | In-stock |
| 50mg | $622 | In-stock |
| 100mg | $840 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100742A |
| M.Wt: | 499.04 |
| Formula: | C25H23ClN2O3S2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
(R)-GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor, with IC50s of 3 nM and 5 nM for LDHA and LDHB, respectively; (R)-GNE-140 is 18-fold more potent than S enantiomer. IC50 & Target: IC50: 3 nM (LDHA), 5 nM (LDHB)[1] In Vitro: (R)-GNE-140 inhibits proliferation in 37 of 347 cancer cell lines tested at a potency cut off of 5 μM. (R)-GNE-140 shows inhibitory effect on two chondrosarcoma (bone) cancer cell lines that harbor IDH1 mutations, with the IC50 of 0.8 μM[1]. In Vivo: (R)-GNE-140 (5 mg/kg) has high bioavailability in mice. At higher oral doses, ranging from 50 to 200 mg/kg, (R)-GNE-140 displays greater exposure.
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