(R)-GNE-140 (Standard)
CAS No. : 2003234-63-5
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| Cat. No. : | HY-100742AR |
| M.Wt: | 499.04 |
| Formula: | C25H23ClN2O3S2 |
| Purity: | >98 % |
| Solubility: |
(R)-GNE-140 (Standard) is the analytical standard of (R)-GNE-140 (HY-100742A). This product is intended for research and analytical applications. (R)-GNE-140 is a potent inhibitor of lactate dehydrogenase (LDH) A, B and C, with IC50 values of 3, 5 and 5 nM against LDHA, LDHB, LDHC, respectively. (R)-GNE-140 blocks the conversion of pyruvate to lactate, reduces lactate production and histone lysine lactylation, and inhibits glycolysis. (R)-GNE-140 attenuates cardiac hypertrophy, alleviates PM2.5-induced pulmonary inflammation and fibrosis, blocks MRSA-induced Arg1 expression. (R)-GNE-140 is applicable to research related to pathological cardiac hypertrophy, pulmonary fibrosis, MRSA infection and pancreatic cancer[1][2][3][4]. IC50 & Target:IC50: 3 nM (LDHA), 5 nM (LDHB)[1]
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