APS-2-79 (hydrochloride)
CAS No. : 2002381-31-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $70 | In-stock |
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| Cat. No. : | HY-100627A |
| M.Wt: | 423.89 |
| Formula: | C23H22ClN3O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
APS-2-79 hydrochloride is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling[1].
IC50 & Target: IC50: 120±23 nM (KSR2)[1]
In Vitro: APS-2-79 (5 μM) suppresses KSR-stimulated MEK and ERK phosphorylation in 293H cells[1].
APS-2-79 (1 μM) enhances the efficacy of the clinical MEK inhibitor trametinib within cancer cell lines containing K-Ras mutations[1]
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